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Ultra-specific and Amplification-free Quantification of Mutant DNA by Single-molecule Kinetic Fingerprinting

Conventional techniques for detecting rare DNA sequences require many cycles of PCR amplification for high sensitivity and specificity, potentially introducing significant biases and errors. While amplification-free methods exist, they rarely achieve the ability to detect single molecules, and their...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Hayward, Stephen L., Lund, Paul E., Kang, Qing, Johnson-Buck, Alexander, Tewari, Muneesh, Walter, Nils G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6157911/
https://ncbi.nlm.nih.gov/pubmed/30125495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b06685
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