Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.

Limited proteolysis of the scrapie prion protein (PrPSc) generates PrP 27-30, which polymerizes into amyloid. By attenuated total reflection-Fourier transform infrared spectroscopy, PrP 27-30 polymers contained 54% beta-sheet, 25% alpha-helix, 10% turns, and 11% random coil; dispersion into detergen...

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Hlavní autoři: Gasset, M, Baldwin, M A, Fletterick, R J, Prusiner, S B
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC45587/
https://ncbi.nlm.nih.gov/pubmed/8419912
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