Perturbation of the secondary structure of the scrapie prion protein under conditions that alter infectivity.

Limited proteolysis of the scrapie prion protein (PrPSc) generates PrP 27-30, which polymerizes into amyloid. By attenuated total reflection-Fourier transform infrared spectroscopy, PrP 27-30 polymers contained 54% beta-sheet, 25% alpha-helix, 10% turns, and 11% random coil; dispersion into detergen...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gasset, M, Baldwin, M A, Fletterick, R J, Prusiner, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45587/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8419912/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.1.1
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