Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

The αβTCR was recently revealed to function as a mechanoreceptor. That is, it leverages mechanical energy generated during immune surveillance and at the immunological synapse to drive biochemical signaling following ligation by a specific foreign peptide–MHC complex (pMHC). Here, we review the stru...

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Udgivet i:Front Immunol
Main Authors: Brazin, Kristine N., Mallis, Robert J., Das, Dibyendu Kumar, Feng, Yinnian, Hwang, Wonmuk, Wang, Jia-huai, Wagner, Gerhard, Lang, Matthew J., Reinherz, Ellis L.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558533/
https://ncbi.nlm.nih.gov/pubmed/26388869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2015.00441
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