Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

The αβ T-cell receptor (TCR) on each T lymphocyte mediates exquisite specificity for a particular foreign peptide bound to a major histocompatibility complex molecule (pMHC) displayed on the surface of altered cells. This recognition stimulates protection in the mammalian host against intracellular...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Das, Dibyendu Kumar, Feng, Yinnian, Mallis, Robert J., Li, Xiaolong, Keskin, Derin B., Hussey, Rebecca E., Brady, Sonia K., Wang, Jia-Huai, Wagner, Gerhard, Reinherz, Ellis L., Lang, Matthew J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4321250/
https://ncbi.nlm.nih.gov/pubmed/25605925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424829112
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