Schistosome-induced cholangiocyte proliferation and osteopontin secretion correlate with fibrosis and portal hypertension in human and murine schistosomiasis mansoni

Schistosomiasis is a major cause of portal hypertension worldwide. It associates with portal fibrosis that develops during chronic infection. The mechanisms by which the pathogen evokes these host responses remain unclear. We evaluated the hypothesis that schistosome eggs release factors that direct...

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Veröffentlicht in:Clin Sci (Lond)
Hauptverfasser: Pereira, Thiago A., Syn, Wing-Kin, Machado, Mariana V., Vidigal, Paula V., Resende, Vivian, Voieta, Izabela, Xie, Guanhua, Otoni, Alba, Souza, Márcia M., Santos, Elisângela T., Chan, Isaac S., Trindade, Guilherme V.M., Choi, Steve S., Witek, Rafal P., Pereira, Fausto E., Secor, William E., Andrade, Zilton A., Lambertucci, José Roberto, Diehl, Anna Mae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Portland Press Ltd. 2015
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Original Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558314/
https://ncbi.nlm.nih.gov/pubmed/26201095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20150117
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