Macrophage-derived Hedgehog Ligands Promotes Fibrogenic and Angiogenic Responses in Human Schistosomiasis mansoni

BACKGROUND: Schistosomiasis mansoni is a major cause of portal fibrosis and portal hypertension. The Hedgehog pathway regulates fibrogenic repair in some types of liver injury. AIMS: Determine if Hedgehog-pathway activation occurs during fibrosis progression in schistosomiasis and to determine if ma...

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Hauptverfasser: Pereira, Thiago A., Xie, Guanhua, Choi, Steve S., Syn, Wing-Kin, Voieta, Izabela, Lu, Jiuyi, Chan, Isaac S., Swiderska, Marzena, Amaral, Kirsten B., Antunes, Carlos Maurício, Secor, William E., Witek, Rafal P., Lambertucci, José Roberto, Pereira, Fausto L., Diehl, Anna Mae
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3518740/
https://ncbi.nlm.nih.gov/pubmed/23121638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/liv.12016
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