RAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors

Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergence of...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J., Zhou, Pengcheng, Dabral, Sukriti K., Pak, Ekaterina, Li, Wei, Atwood, Scott X., Whitson, Ramon J., Chang, Anne Lynn S., Li, Jiang, Oro, Anthony E., Chan, Jennifer A., Kelleher, Joseph F., Segal, Rosalind A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558230/
https://ncbi.nlm.nih.gov/pubmed/26130651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2999-T
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker