RAS/MAPK activation drives resistance to Smo inhibition, metastasis and tumor evolution in Shh pathway-dependent tumors

Aberrant Shh signaling promotes tumor growth in diverse cancers. The importance of Shh signaling is particularly evident in medulloblastoma and basal cell carcinoma (BCC), where inhibitors targeting the Shh pathway component Smoothened (Smo) show great therapeutic promise. However, the emergence of...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Zhao, Xuesong, Ponomaryov, Tatyana, Ornell, Kimberly J., Zhou, Pengcheng, Dabral, Sukriti K., Pak, Ekaterina, Li, Wei, Atwood, Scott X., Whitson, Ramon J., Chang, Anne Lynn S., Li, Jiang, Oro, Anthony E., Chan, Jennifer A., Kelleher, Joseph F., Segal, Rosalind A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558230/
https://ncbi.nlm.nih.gov/pubmed/26130651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2999-T
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