Loss of primary cilia drives switching from Hedgehog to Ras/MAPK pathway in resistant basal cell carcinoma

Basal cell carcinomas (BCCs) rely on Hedgehog (HH) pathway growth signal amplification by the microtubule-based organelle, the primary cilium. Despite naive tumors responsiveness to Smoothened inhibitors (Smo(i)), resistance in advanced tumors remains frequent. While the resistant BCCs usually maint...

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Vydáno v:J Invest Dermatol
Hlavní autoři: Kuonen, François, Huskey, Noelle E., Shankar, Gautam, Jaju, Prajakta, Whitson, Ramon J., Rieger, Kerri E., Atwood, Scott X., Sarin, Kavita Y., Oro, Anthony E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591089/
https://ncbi.nlm.nih.gov/pubmed/30707899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.11.035
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