Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas

Hedgehog pathway-dependent cancers can escape smoothened (SMO) inhibition through canonical pathway mutations, however, 50% of resistant BCCs lack additional variants in hedgehog genes. Here we use multi-dimensional genomics in human and mouse resistant BCCs to identify a non-canonical hedgehog acti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nat Med
Egile Nagusiak: Whitson, Ramon J., Lee, Alex, Urman, Nicole M., Mirza, Amar, Yao, Catherine Y., Brown, Alexander S., Li, Jiang R., Shankar, Gautam, Fry, Micah A., Atwood, Scott X., Hollmig, S. Tyler, Aasi, Sumaira Z., Sarin, Kavita Y., Epstein, Ervin H., Tang, Jean Y., Oro, Anthony E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839965/
https://ncbi.nlm.nih.gov/pubmed/29400712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4476
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak