Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas

Hedgehog pathway-dependent cancers can escape smoothened (SMO) inhibition through canonical pathway mutations, however, 50% of resistant BCCs lack additional variants in hedgehog genes. Here we use multi-dimensional genomics in human and mouse resistant BCCs to identify a non-canonical hedgehog acti...

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Foilsithe in:Nat Med
Main Authors: Whitson, Ramon J., Lee, Alex, Urman, Nicole M., Mirza, Amar, Yao, Catherine Y., Brown, Alexander S., Li, Jiang R., Shankar, Gautam, Fry, Micah A., Atwood, Scott X., Hollmig, S. Tyler, Aasi, Sumaira Z., Sarin, Kavita Y., Epstein, Ervin H., Tang, Jean Y., Oro, Anthony E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839965/
https://ncbi.nlm.nih.gov/pubmed/29400712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4476
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