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Non-canonical hedgehog pathway activation by MKL1/SRF promotes drug-resistance in basal cell carcinomas
Hedgehog pathway-dependent cancers can escape smoothened (SMO) inhibition through canonical pathway mutations, however, 50% of resistant BCCs lack additional variants in hedgehog genes. Here we use multi-dimensional genomics in human and mouse resistant BCCs to identify a non-canonical hedgehog acti...
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| Опубликовано в: : | Nat Med |
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| Главные авторы: | , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5839965/ https://ncbi.nlm.nih.gov/pubmed/29400712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4476 |
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