Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment

Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious therapies. We performed a gene expression–based drug r...

詳細記述

保存先:
書誌詳細
出版年:JCI Insight
主要な著者: Mirza, Amar N., Fry, Micah A., Urman, Nicole M., Atwood, Scott X., Roffey, Jon, Ott, Gregory R., Chen, Bin, Lee, Alex, Brown, Alexander S., Aasi, Sumaira Z., Hollmig, Tyler, Ator, Mark A., Dorsey, Bruce D., Ruggeri, Bruce R., Zificsak, Craig A., Sirota, Marina, Tang, Jean Y., Butte, Atul, Epstein, Ervin, Sarin, Kavita Y., Oro, Anthony E.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2017
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752280/
https://ncbi.nlm.nih.gov/pubmed/29093271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97071
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