Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment

Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious therapies. We performed a gene expression–based drug r...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mirza, Amar N., Fry, Micah A., Urman, Nicole M., Atwood, Scott X., Roffey, Jon, Ott, Gregory R., Chen, Bin, Lee, Alex, Brown, Alexander S., Aasi, Sumaira Z., Hollmig, Tyler, Ator, Mark A., Dorsey, Bruce D., Ruggeri, Bruce R., Zificsak, Craig A., Sirota, Marina, Tang, Jean Y., Butte, Atul, Epstein, Ervin, Sarin, Kavita Y., Oro, Anthony E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752280/
https://ncbi.nlm.nih.gov/pubmed/29093271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97071
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