Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment

Advanced basal cell carcinomas (BCCs) circumvent Smoothened (SMO) inhibition by activating GLI transcription factors to sustain the high levels of Hedgehog (HH) signaling required for their survival. Unfortunately, there is a lack of efficacious therapies. We performed a gene expression–based drug r...

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Pubblicato in:JCI Insight
Autori principali: Mirza, Amar N., Fry, Micah A., Urman, Nicole M., Atwood, Scott X., Roffey, Jon, Ott, Gregory R., Chen, Bin, Lee, Alex, Brown, Alexander S., Aasi, Sumaira Z., Hollmig, Tyler, Ator, Mark A., Dorsey, Bruce D., Ruggeri, Bruce R., Zificsak, Craig A., Sirota, Marina, Tang, Jean Y., Butte, Atul, Epstein, Ervin, Sarin, Kavita Y., Oro, Anthony E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752280/
https://ncbi.nlm.nih.gov/pubmed/29093271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97071
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