Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility

Innate DNA repair mechanisms play a critical role in protecting skin keratinocytes from UV mutagenesis and skin cancer development. We hypothesized that individuals who develop frequent skin cancers may harbor germline defects in DNA repair genes and have increased predisposition to internal maligna...

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Publicat a:JCI Insight
Autors principals: Cho, Hyunje G., Kuo, Karen Y., Li, Shufeng, Bailey, Irene, Aasi, Sumaira, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y., Sarin, Kavita Y.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129130/
https://ncbi.nlm.nih.gov/pubmed/30089731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122744
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