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Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility

Innate DNA repair mechanisms play a critical role in protecting skin keratinocytes from UV mutagenesis and skin cancer development. We hypothesized that individuals who develop frequent skin cancers may harbor germline defects in DNA repair genes and have increased predisposition to internal maligna...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Cho, Hyunje G., Kuo, Karen Y., Li, Shufeng, Bailey, Irene, Aasi, Sumaira, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y., Sarin, Kavita Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129130/
https://ncbi.nlm.nih.gov/pubmed/30089731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122744
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