Frequent basal cell cancer development is a clinical marker for inherited cancer susceptibility

Innate DNA repair mechanisms play a critical role in protecting skin keratinocytes from UV mutagenesis and skin cancer development. We hypothesized that individuals who develop frequent skin cancers may harbor germline defects in DNA repair genes and have increased predisposition to internal maligna...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Cho, Hyunje G., Kuo, Karen Y., Li, Shufeng, Bailey, Irene, Aasi, Sumaira, Chang, Anne Lynn S., Oro, Anthony E., Tang, Jean Y., Sarin, Kavita Y.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129130/
https://ncbi.nlm.nih.gov/pubmed/30089731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122744
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