A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

Notochord-derived Sonic Hedgehog (Shh) is essential for dorsoventral patterning of the overlying neural tube. Increasing concentration and duration of Shh signal induces progenitors to acquire progressively more ventral fates. We show that Notch signalling augments the response of neuroepithelial ce...

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Veröffentlicht in:Development
Hauptverfasser: Stasiulewicz, Magdalena, Gray, Shona D., Mastromina, Ioanna, Silva, Joana C., Björklund, Mia, Seymour, Philip A., Booth, David, Thompson, Calum, Green, Richard J., Hall, Emma A., Serup, Palle, Dale, J. Kim
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4510595/
https://ncbi.nlm.nih.gov/pubmed/25995356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.125237
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