EPCT-25. SMO PROTEIN DEPLETION IN SHH MEDULLOBLASTOMAS USING MICROBUBBLE-ENHANCED ULTRASOUND AND SIRNA LOADED CATIONIC NANOPARTICLES

RNA-based therapies offer unique advantages for treating pediatric brain tumors. However, the systemic delivery remains a major problem due to degradation of unmodified RNA in biological fluids, poor brain accumulation, and poor cancer cell uptake or escape from the endosomal lipid bilayer barrier....

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Guo, Yutong, Lee, Hohyun, Fang, Zhou, Velalopoulou, Anastasia, Kim, Jinhwan, Thomas, Midhun Ben, Liu, Jingbo, Abramowitz, Ryan G, Kim, YongTae, Coskun, Ahmet F, Krummel, Daniel Pomeranz, Sengupta, Soma, MacDonald, Tobey J, Arvanitis, Costas
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2021
Fag:
Translational/Early Phase Clinical Trials
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168192/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noab090.211
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