Structure–Activity Relationship Studies and in Vivo Activity of Guanidine-Based Sphingosine Kinase Inhibitors: Discovery of SphK1- and SphK2-Selective Inhibitors

[Image: see text] Sphingosine 1-phosphate (S1P) is a pleiotropic signaling molecule that acts as a ligand for five G-protein coupled receptors (S1P(1–5)) whose downstream effects are implicated in a variety of important pathologies including sickle cell disease, cancer, inflammation, and fibrosis. T...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Patwardhan, Neeraj N., Morris, Emily A., Kharel, Yugesh, Raje, Mithun R., Gao, Ming, Tomsig, Jose L., Lynch, Kevin R., Santos, Webster L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557804/
https://ncbi.nlm.nih.gov/pubmed/25643074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501760d
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