A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signa...

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Udgivet i:Nat Commun
Main Authors: Uno, Kenji, Yamada, Tetsuya, Ishigaki, Yasushi, Imai, Junta, Hasegawa, Yutaka, Sawada, Shojiro, Kaneko, Keizo, Ono, Hiraku, Asano, Tomoichiro, Oka, Yoshitomo, Katagiri, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557134/
https://ncbi.nlm.nih.gov/pubmed/26268630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8940
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