Neuronal signals regulate obesity induced β-cell proliferation by FoxM1 dependent mechanism

Under insulin-resistant conditions such as obesity, pancreatic β-cells proliferate to prevent blood glucose elevations. A liver–brain–pancreas neuronal relay plays an important role in this process. Here, we show the molecular mechanism underlying this compensatory β-cell proliferation. We identify...

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Udgivet i:Nat Commun
Main Authors: Yamamoto, Junpei, Imai, Junta, Izumi, Tomohito, Takahashi, Hironori, Kawana, Yohei, Takahashi, Kei, Kodama, Shinjiro, Kaneko, Keizo, Gao, Junhong, Uno, Kenji, Sawada, Shojiro, Asano, Tomoichiro, Kalinichenko, Vladimir V., Susaki, Etsuo A., Kanzaki, Makoto, Ueda, Hiroki R., Ishigaki, Yasushi, Yamada, Tetsuya, Katagiri, Hideki
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717276/
https://ncbi.nlm.nih.gov/pubmed/29208957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01869-7
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