A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signa...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Uno, Kenji, Yamada, Tetsuya, Ishigaki, Yasushi, Imai, Junta, Hasegawa, Yutaka, Sawada, Shojiro, Kaneko, Keizo, Ono, Hiraku, Asano, Tomoichiro, Oka, Yoshitomo, Katagiri, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557134/
https://ncbi.nlm.nih.gov/pubmed/26268630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8940
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