Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-Cells: Potential Involvement of the PLC-IP(3)–Dependent Pathway

OBJECTIVE: Interleukin-6 (IL-6) has a significant impact on glucose metabolism. However, the effects of IL-6 on insulin secretion from pancreatic β-cells are controversial. Therefore, we analyzed IL-6 effects on pancreatic β-cell functions both in vivo and in vitro. RESEARCH DESIGN AND METHODS: Firs...

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Detalhes bibliográficos
Main Authors: Suzuki, Toshinobu, Imai, Junta, Yamada, Tetsuya, Ishigaki, Yasushi, Kaneko, Keizo, Uno, Kenji, Hasegawa, Yutaka, Ishihara, Hisamitsu, Oka, Yoshitomo, Katagiri, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028353/
https://ncbi.nlm.nih.gov/pubmed/21270264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0796
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