A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals

Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signa...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Uno, Kenji, Yamada, Tetsuya, Ishigaki, Yasushi, Imai, Junta, Hasegawa, Yutaka, Sawada, Shojiro, Kaneko, Keizo, Ono, Hiraku, Asano, Tomoichiro, Oka, Yoshitomo, Katagiri, Hideki
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4557134/
https://ncbi.nlm.nih.gov/pubmed/26268630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8940
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