GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Gastrointest Liver Physiol
Prif Awduron: Johansson, Maja, Agusti, Ana, Llansola, Marta, Montoliu, Carmina, Strömberg, Jessica, Malinina, Evgenya, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn, Felipo, Vicente
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2015
Pynciau:
Liver and Biliary Tract Physiology/Pathophysiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556948/
https://ncbi.nlm.nih.gov/pubmed/26138462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2015
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