GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations....

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Publicat a:Am J Physiol Gastrointest Liver Physiol
Autors principals: Johansson, Maja, Agusti, Ana, Llansola, Marta, Montoliu, Carmina, Strömberg, Jessica, Malinina, Evgenya, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn, Felipo, Vicente
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2015
Matèries:
Liver and Biliary Tract Physiology/Pathophysiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556948/
https://ncbi.nlm.nih.gov/pubmed/26138462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2015
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