GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations....

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Gastrointest Liver Physiol
Hoofdauteurs: Johansson, Maja, Agusti, Ana, Llansola, Marta, Montoliu, Carmina, Strömberg, Jessica, Malinina, Evgenya, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn, Felipo, Vicente
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2015
Onderwerpen:
Liver and Biliary Tract Physiology/Pathophysiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556948/
https://ncbi.nlm.nih.gov/pubmed/26138462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2015
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