GR3027 antagonizes GABA(A) receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy

Hepatic encephalopathy (HE) is one of the primary complications of liver cirrhosis. Current treatments for HE, mainly directed to reduction of ammonia levels, are not effective enough because they cannot completely eliminate hyperammonemia and inflammation, which induce the neurological alterations....

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Gastrointest Liver Physiol
Asıl Yazarlar: Johansson, Maja, Agusti, Ana, Llansola, Marta, Montoliu, Carmina, Strömberg, Jessica, Malinina, Evgenya, Ragagnin, Gianna, Doverskog, Magnus, Bäckström, Torbjörn, Felipo, Vicente
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2015
Konular:
Liver and Biliary Tract Physiology/Pathophysiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556948/
https://ncbi.nlm.nih.gov/pubmed/26138462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2015
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