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GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study

RATIONALE: GR3027 is a novel small molecule GABA-A receptor-modulating steroid antagonist, which in non-clinical studies has shown promise for treatment of human disorders due to allosteric over-activation of GABA-A receptors by neurosteroids, such as allopregnanolone. We here studied its safety, ph...

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Detalhes bibliográficos
Publicado no:Psychopharmacology (Berl)
Main Authors: Johansson, Maja, Månsson, Maria, Lins, Lars-Eric, Scharschmidt, Bruce, Doverskog, Magnus, Bäckström, Torbjörn
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5919995/
https://ncbi.nlm.nih.gov/pubmed/29492615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-018-4864-1
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