HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines

Signal transducer and activator of transcription factor 3 (STAT3) is hyperactivated in head and neck squamous cell carcinomas (HNSCC). Cumulative evidence indicates that IL-6 production by HNSCC cells and/or stromal cells in the tumor microenvironment activates STAT3 and contributes to tumor progres...

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Bibliographische Detailangaben
Veröffentlicht in:Assay Drug Dev Technol
Hauptverfasser: Johnston, Paul A., Sen, Malabika, Hua, Yun, Camarco, Daniel P., Shun, Tong Ying, Lazo, John S., Wilson, Gabriela Mustata, Resnick, Lynn O., LaPorte, Matthew G., Wipf, Peter, Huryn, Donna M., Grandis, Jennifer R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556090/
https://ncbi.nlm.nih.gov/pubmed/26317883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/adt.2015.663
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