Structural constraints determine the glycosylation of HIV-1 envelope trimers

A highly glycosylated, trimeric envelope glycoprotein (Env) mediates HIV-1 cell entry. The high density and heterogeneity of the glycans shield Env from recognition by the immune system but, paradoxically, many potent broadly neutralizing antibodies (bNAbs) recognize epitopes involving this glycan s...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Pritchard, Laura K., Vasiljevic, Snezana, Ozorowski, Gabriel, Seabright, Gemma E., Cupo, Albert, Ringe, Rajesh, Kim, Helen J., Sanders, Rogier W., Doores, Katie J., Burton, Dennis R., Wilson, Ian A., Ward, Andrew B., Moore, John P., Crispin, Max
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555872/
https://ncbi.nlm.nih.gov/pubmed/26051934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.017
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