Structural constraints determine the glycosylation of HIV-1 envelope trimers

A highly glycosylated, trimeric envelope glycoprotein (Env) mediates HIV-1 cell entry. The high density and heterogeneity of the glycans shield Env from recognition by the immune system but, paradoxically, many potent broadly neutralizing antibodies (bNAbs) recognize epitopes involving this glycan s...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Pritchard, Laura K., Vasiljevic, Snezana, Ozorowski, Gabriel, Seabright, Gemma E., Cupo, Albert, Ringe, Rajesh, Kim, Helen J., Sanders, Rogier W., Doores, Katie J., Burton, Dennis R., Wilson, Ian A., Ward, Andrew B., Moore, John P., Crispin, Max
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555872/
https://ncbi.nlm.nih.gov/pubmed/26051934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.017
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