15q12 Variants, Sputum Gene Promoter Hypermethylation, and Lung Cancer Risk: A GWAS in Smokers

BACKGROUND: Lung cancer is the leading cause of cancer-related mortality worldwide. Detection of promoter hypermethylation of tumor suppressor genes in exfoliated cells from the lung provides an assessment of field cancerization that in turn predicts lung cancer. The identification of genetic determ...

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Publicado en:J Natl Cancer Inst
Main Authors: Leng, Shuguang, Liu, Yushi, Weissfeld, Joel L., Thomas, Cynthia L., Han, Younghun, Picchi, Maria A., Edlund, Christopher K., Willink, Randall P., Gaither Davis, Autumn L., Do, Kieu C., Nukui, Tomoko, Zhang, Xiequn, Burki, Elizabeth A., Van Den Berg, David, Romkes, Marjorie, Gauderman, W. James, Crowell, Richard E., Tesfaigzi, Yohannes, Stidley, Christine A., Amos, Christopher I., Siegfried, Jill M., Gilliland, Frank D., Belinsky, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555640/
https://ncbi.nlm.nih.gov/pubmed/25713168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djv035
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