Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion

BACKGROUND: Chronic mucous hypersecretion (CMH) contributes to COPD exacerbations and increased risk for lung cancer. Because methylation of gene promoters in sputum has been shown to be associated with lung cancer risk, we tested whether such methylation was more common in persons with CMH. METHODS...

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Detalhes bibliográficos
Main Authors: Bruse, Shannon, Petersen, Hans, Weissfeld, Joel, Picchi, Maria, Willink, Randall, Do, Kieu, Siegfried, Jill, Belinsky, Steven A, Tesfaigzi, Yohannes
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3893562/
https://ncbi.nlm.nih.gov/pubmed/24405663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-2
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