Gene Promoter Hypermethylation Detected in Sputum Predicts FEV(1) Decline and All-Cause Mortality in Smokers

Rationale: Gene promoter hypermethylation detected in sputum assesses the extent of field cancerization and predicts lung cancer (LC) risk in ever-smokers. A rapid decline of FEV(1) is a major driver for development of airway obstruction. Objectives: To assess the effects of methylation of 12 genes...

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Vydáno v:Am J Respir Crit Care Med
Hlavní autoři: Leng, Shuguang, Diergaarde, Brenda, Picchi, Maria A., Wilson, David O., Gilliland, Frank D., Yuan, Jian-Min, Siegfried, Jill M., Belinsky, Steven A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2018
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058990/
https://ncbi.nlm.nih.gov/pubmed/29437466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201708-1659OC
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