Genetic Determinants for Promoter Hypermethylation in the Lungs of Smokers: A Candidate Gene-Based Study

The detection of tumor suppressor gene promoter methylation in sputum-derived exfoliated cells predicts early lung cancer. Here we identified genetic determinants for this epigenetic process and examined their biological effects on gene regulation. A two-stage approach involving discovery and replic...

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Detalhes bibliográficos
Main Authors: Leng, Shuguang, Stidley, Christine A., Liu, Yushi, Edlund, Christopher K., Willink, Randall P., Han, Younghun, Landi, Maria Teresa, Thun, Michael, Picchi, Maria A., Bruse, Shannon E., Crowell, Richard E., Van Den Berg, David, Caporaso, Neil E., Amos, Christopher I., Siegfried, Jill M., Tesfaigzi, Yohannes, Gilliland, Frank D., Belinsky, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271143/
https://ncbi.nlm.nih.gov/pubmed/22139380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3194
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