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Structural Modeling Insights into Human VKORC1 Phenotypes

Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) catalyses the reduction of vitamin K and its 2,3-epoxide essential to sustain γ-carboxylation of vitamin K-dependent proteins. Two different phenotypes are associated with mutations in human VKORC1. The majority of mutations cause resistance...

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Detalhes bibliográficos
Publicado no:Nutrients
Main Authors: Czogalla, Katrin J., Watzka, Matthias, Oldenburg, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4555152/
https://ncbi.nlm.nih.gov/pubmed/26287237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/nu7085313
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