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VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites
Vitamin K reduction is catalyzed by 2 enzymes in vitro: the vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) and its isozyme VKORC1-like1 (VKORC1L1). In vivo, VKORC1 reduces vitamin K to sustain γ-carboxylation of vitamin K-dependent proteins, including coagulation factors. Inhibition of V...
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| Publicado no: | Blood Adv |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5873226/ https://ncbi.nlm.nih.gov/pubmed/29581108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006775 |
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