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Irreversible binding of an anticancer compound (BI-94) to plasma proteins
1. We investigated the mechanisms responsible for the in vivo instability of a benzofurazan compound BI-94 (NSC228148) with potent anti-cancer activity. 2. BI-94 was stable in MeOH, water, and in various buffers at pHs 2.5–5, regardless of the buffer composition. In contrast, BI-94 was unstable in N...
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| Publicado en: | Xenobiotica |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4553108/ https://ncbi.nlm.nih.gov/pubmed/25869245 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/00498254.2015.1025250 |
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