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Pharmacokinetics, protein binding, and metabolism of a quinoxaline urea analog as a NF-кB inhibitor in mice and rats by LC-MS/MS
13–197 is a novel NF-ĸB inhibitor that shows promising in-vitro efficacy data against pancreatic cancer. In this study, we characterized the pharmacokinetics (PK), tissue distribution, protein binding, and metabolism of 13–197 in mice and rats. A valid, sensitive, and selective LC-MS/MS method was d...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3760428/ https://ncbi.nlm.nih.gov/pubmed/23483555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.2880 |
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