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Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

PURPOSE: The presence of TNFα in ~ 50% of surgically resected tumors suggests that the canonical NF-κB and the mTOR pathways are activated. IκB kinase β (IKKβ) acts as the signaling node that regulates transcription via the p-IκBα/NF-κB axis and regulates translation via the mTOR/p-S6K/p-eIF4EBP axi...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Radhakrishnan, Prakash, Bryant, Vashti C., Blowers, Elizabeth C., Rajule, Rajkumar N., Gautam, Nagsen, Anwar, Muhammad M., Mohr, Ashley M, Grandgenett, Paul M, Bunt, Stephanie K, Arnst, Jamie L., Lele, Subodh M., Alnouti, Yazen, Hollingsworth, Michael A., Natarajan, Amarnath
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	2013
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3630250/ https://ncbi.nlm.nih.gov/pubmed/23444213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-2909
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Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

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