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Perturbing pro-survival proteins using quinoxaline derivatives: A structure activity relationship study

In HeLa cells the combinatorial knockdown of Bcl-xL and Mcl-1 is sufficient to induce spontaneous apoptosis. Quinoxaline derivatives were screened for the induction of Mcl-1 dependent apoptosis using a cell line without functional Bcl-xL. Quinoxaline urea analog 1h was able to specifically induce ap...

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Détails bibliographiques
Auteurs principaux: Rajule, Rajkumar, Bryant, Vashti C., Lopez, Hernando, Luo, Xu, Natarajan, Amarnath
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303926/
https://ncbi.nlm.nih.gov/pubmed/22386982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.022
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