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Perturbing pro-survival proteins using quinoxaline derivatives: A structure activity relationship study
In HeLa cells the combinatorial knockdown of Bcl-xL and Mcl-1 is sufficient to induce spontaneous apoptosis. Quinoxaline derivatives were screened for the induction of Mcl-1 dependent apoptosis using a cell line without functional Bcl-xL. Quinoxaline urea analog 1h was able to specifically induce ap...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3303926/ https://ncbi.nlm.nih.gov/pubmed/22386982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.02.022 |
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