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A quinoxaline urea analog uncouples inflammatory and pro-survival functions of IKKβ
Activation of the NF-κB pathway is causally linked to initiation and progression of diverse cancers. Therefore, IKKβ, the key regulatory kinase of the canonical NF-κB pathway, should be a logical target for cancer treatment. However, existing IKKβ inhibitors are known to induce paradoxical immune ac...
Sparad:
| I publikationen: | Immunol Lett |
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| Huvudupphovsmän: | , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2015
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4688189/ https://ncbi.nlm.nih.gov/pubmed/26518140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2015.10.011 |
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