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Targeted Knockdown of Hepatic SOAT2 with Antisense Oligonucleotides Stabilizes Atherosclerotic Plaque in ApoB100-only LDLr(−/−) Mice

OBJECTIVE: To test the hypothesis that the attenuation of CO packaging into apoB-containing lipoproteins will arrest progression of pre-existing atherosclerotic lesions. APPROACH AND RESULTS: Atherosclerosis was induced in apoB-100 only, LDLr(−/−) mice by feeding a diet enriched in cis-monounsaturat...

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Bibliografske podrobnosti
izdano v:Arterioscler Thromb Vasc Biol
Main Authors: Melchior, John T., Olson, John D., Kelley, Kathryn L., Wilson, Martha D., Sawyer, Janet K., Link, Kerry M., Rudel, Lawrence L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552612/
https://ncbi.nlm.nih.gov/pubmed/26229140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.305747
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