8-Chloroadenosine Sensitivity in Renal Cell Carcinoma Is Associated with AMPK Activation and mTOR Pathway Inhibition

The adenosine analog 8-chloroadenosine has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines. We investigated effects of 8-chloroadenosine on clear cell (cc) renal cell carcinoma (RCC) cell lines. 8-chloroadenosine was ef...

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發表在:PLoS One
Main Authors: Kearney, Alper Y., Fan, You-Hong, Giri, Uma, Saigal, Babita, Gandhi, Varsha, Heymach, John V., Zurita, Amado J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4552467/
https://ncbi.nlm.nih.gov/pubmed/26313261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135962
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