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Intracellular Succinylation of 8-Chloroadenosine and Its Effect on Fumarate Levels
8-Chloroadenosine (8-Cl-Ado) is a ribosyl nucleoside analog currently in phase I testing for the treatment of chronic lymphocytic leukemia (CLL). 8-Cl-Ado activity is dependent on adenosine kinase and requires intracellular accumulation of 8-Cl-Ado as mono-, di-, and tri-phosphates. In the current s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2832953/ https://ncbi.nlm.nih.gov/pubmed/20064937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.085803 |
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