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A unique RNA-directed nucleoside analog is cytotoxic to breast cancer cells and depletes cyclin E levels
In contrast to deoxyribose or arabinose containing nucleoside analogs that are currently established for cancer therapeutics, 8-chloro-adenosine (8-Cl-Ado) possesses a ribose sugar. This unique nucleoside analog is RNA-directed and is in a phase I clinical trial for hematological malignancies. RNA-d...
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| Publicado no: | Breast Cancer Res Treat |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5739050/ https://ncbi.nlm.nih.gov/pubmed/19641990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-009-0481-3 |
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