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Destabilization of microRNAs in human cells by 3′ deadenylation mediated by PARN and CUGBP1
MicroRNA-122 (miR-122), which is expressed at high levels in hepatocytes, is selectively stabilized by 3′-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Here, we report that poly(A)-specific ribonuclease (PARN) is responsible for the deadenylation and destabilization of miR-122. T...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4551920/ https://ncbi.nlm.nih.gov/pubmed/26130707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv669 |
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