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The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3′ adenylation and selective stabilization of microRNA-122

MicroRNA-122 (miR-122) is highly expressed in hepatocytes, where it plays an important role in regulating cholesterol and fatty acid metabolism, and it is also a host factor required for hepatitis C virus replication. miR-122 is selectively stabilized by 3′ adenylation mediated by the cytoplasmic po...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hojo, Hiroaki, Yashiro, Yuka, Noda, Yuta, Ogami, Koichi, Yamagishi, Ryota, Okada, Shunpei, Hoshino, Shin-ichi, Suzuki, Tsutomu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2020
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956528/
https://ncbi.nlm.nih.gov/pubmed/31792053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011617
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