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The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers

[Image: see text] Liver phenylalanine hydroxylase is allosterically activated by phenylalanine. The structural changes that accompany activation have not been identified, but recent studies of the effects of phenylalanine on the isolated regulatory domain of the enzyme support a model in which pheny...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Zhang, Shengnan, Hinck, Andrew P., Fitzpatrick, Paul F.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4551101/
https://ncbi.nlm.nih.gov/pubmed/26252467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00616
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