Učitavanje...
A single-chain variable fragment intrabody prevents intracellular polymerization of Z α(1)-antitrypsin while allowing its antiproteinase activity
Mutant Z α(1)-antitrypsin (E342K) accumulates as polymers within the endoplasmic reticulum (ER) of hepatocytes predisposing to liver disease, whereas low levels of circulating Z α(1)-antitrypsin lead to emphysema by loss of inhibition of neutrophil elastase. The ideal therapy should prevent polymer...
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| Izdano u: | FASEB J |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Federation of American Societies for Experimental Biology
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4548814/ https://ncbi.nlm.nih.gov/pubmed/25757566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-267351 |
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