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Altered native stability is the dominant basis for susceptibility of α(1)-antitrypsin mutants to polymerization
Serpins are protease inhibitors whose most stable state is achieved upon transition of a central 5-stranded β-sheet to a 6-stranded form. Mutations, low pH, denaturants and elevated temperatures promote this transition, which can result in a growing polymer chain of inactive molecules. Different typ...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Portland Press Ltd.
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4080824/ https://ncbi.nlm.nih.gov/pubmed/24552432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20131650 |
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