The structural basis for Z α(1)-antitrypsin polymerization in the liver

The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. α(1)-Antitrypsin deficiency is the archetypal serpinopathy and results from the formation and deposition of mutant forms of α(1)-antitrypsin as “polym...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Faull, Sarah V., Elliston, Emma L. K., Gooptu, Bibek, Jagger, Alistair M., Aldobiyan, Ibrahim, Redzej, Adam, Badaoui, Magd, Heyer-Chauhan, Nina, Rashid, S. Tamir, Reynolds, Gary M., Adams, David H., Miranda, Elena, Orlova, Elena V., Irving, James A., Lomas, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577719/
https://ncbi.nlm.nih.gov/pubmed/33087346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abc1370
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